Loxosceles reclusa and its sister species in Chile are very poisonous spider. But on the positive side for human. they have a tiny fangs and it is difficult to pierce clothing. They also named the hermit, their will not have a lot of bites because they love hidden. The most dangerous symptom after been bite is bone necrosis in tissue , and the wound may be extended to 10 inches and began to rot. Chile hidden spider are more toxic, some systemic infections even lead to kidney failure. One study showed that deaths in Chile accounted for 3% -4% of all bites, its median lethal dose of 1.45mg/kg, so it is obvious that it is a need to avoid spider
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Reference:
http://www.spiders.us/species/loxosceles-reclusa/
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